Indication for Use
NEXCHANGE™ KIT is indicated for the treatment of periprosthetic joint infection (PJI) in skeletally mature adult patients undergoing exchange arthroplasty, where vancomycin hydrochloride and tobramycin sulfate for irrigation are appropriate antibiotics. 
To reduce the development of drug-resistant bacteria and maintain the effectiveness of NEXCHANGE Drug Pack (tobramycin sulfate for irrigation; vancomycin hydrochloride for irrigation) and other antibacterial drugs, NEXCHANGE Drug Pack should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.

 

Select Safety Information
Warnings and precautions include allergic reaction, Clostridium Difficile associated diarrhea, muscle weakness, management of anticoagulation and risk of thromboembolism. Laboratory tests are recommended to monitor for ototoxicity and nephrotoxicity. Monitor patients for increased risk of bleeding. The most common adverse events include post-procedural pain and postoperative anemia.